Staff: Patrick F. Sullivan | Helena Furberg Barnes | Molly Losh | Jim Crowley | Thomas Konneker | Andrea Byrnes
Affiliates: Cynthia Bulik, PhD | Robert K. McClure | Laura Marie Thornton | Tammy Root | Rebecca Knickmeyer | Lauren Reba-Harrelson
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Patrick F. Sullivan
Distinguished Professor, Genetics, Psychiatry, & Epidemiology
Foreign Adjunct Professor, Karolinska Institutet
University of Notre Dame, BS, 1981
University of California, San Francisco, MD, 1988
Royal Australian & New Zealand College of Psychiatrists, 1994
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Factoid: Ran for Adidas for 5 years, black belt in TKD. Concepts to live by: RTFM, eschew black boxes, "it depends...", love the H0.
Favorite Movie: Rashomon
Ancestry: German>Irish (despite the name)
Ability to roll tongue?: HIPAA prohibits disclosure
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pfsulliv@med.unc.edu
919-966-2839
No Bio.
 2006-08 R01 MH074027 PI
2007-12 R01 MH079799 (PI Smoller) Co-investigator
Dr. Sullivan has 170 total publications (153 journal articles, 17 chapters or invited articles, and 2 miscellaneous items). Recent papers are shown below.
Furberg, H., P. Lichtenstein, N. L. Pedersen, C. M. Bulik and P. F. Sullivan (In press). Cigarettes and oral snuff use in Sweden: prevalence and transitions. Addiction. - (in press)
Kato, K., P. Sullivan, B. Evengard and N. L. Pedersen (In press). Chronic widespread pain and its comorbidities: A population-based study. Archives of Internal Medicine. - (in press)
Lichtenstein, P., C. Bjork, C. M. Hultman, E. M. Scolnick, P. Sklar and P. F. Sullivan (In press). Recurrence risks for schizophrenia in a Swedish national cohort. Psychological Medicine. - (in press)
Pinheiro, A., R. Keefe, T. Skelly, M. Olarte, K. Leviel, L. Lange, E. M. Lange, T. Stroup, J. Lieberman and P. F. Sullivan (In press). AKT1 and neurocognition in schizophrenia. Australian and New Zealand Journal of Psychiatry. - (in press)
Sullivan, P. F., P.-H. Kuo, B. T. Webb, M. C. Neale, J. Vittum, H. Furberg, D. Walsh, D. G. Patterson, B. Riley, C. A. Prescott and K. S. Kendler (Submitted). Genomewide linkage survey of nicotine dependence phenotypes. - (in press)
Sullivan, P. F., G. W. Montgomery, J. J. Hottenga, N. R. Wray, D. I. Boomsma and N. G. Martin (In press). Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markers. Twin Res Hum Genet. - (in press)
Hemminger, B. M., B. Saelim and P. F. Sullivan (2006). TAMAL: An integrated approach to choosing SNPs for genetic studies of human complex traits. Bioinformatics 22: 626-7. - 2006
Sullivan, P. F., B. Evengard, A. Jacks and N. L. Pedersen (2005). Twin analyses of chronic fatigue in a Swedish national sample. Psychol Med 35(9): 1327-36. - 2005
Perkins, D. O., C. Jeffries and P. Sullivan (2004). Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia. Mol Psychiatry 10: 69-78. - 2004
Sullivan, P. F., R. S. E. Keefe, L. A. Lange, E. M. Lange, T. S. Stroup, J. A. Lieberman and P. F. Maness (In press). NCAM1 and neurocognition in schizophrenia. Biological Psychiatry.Sullivan, P. F., K. S. Kendler and M. C. Neale (2003). Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Archives of General Psychiatry 60: 1187-92. - 2003
Sullivan, P. F., B. M. Neale, M. C. Neale, E. J. C. G. van den Oord and K. S. Kendler (2003). Multipoint and single point non-parametric linkage analysis with imperfect data. Am J Med Genet 121B: 89-94. - 2003
van den Oord, E. J. and P. F. Sullivan (2003). A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations. Hum Hered 56(4): 188-99. - 2003
van den Oord, E. J. C. G., P. F. Sullivan, X. Jiang, D. Walsh, F. A. O'Neill, K. S. Kendler and B. Riley (2003). Identification of a high risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish Study of High Density Schizophrenia families. Molecular Psychiatry 8: 499-510. - 2003
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Helena Furberg Barnes
Assistant Professor, UNC Department of Genetics
UNC, PhD Epidemiology, 2001
UNC, MSPH Epidemiology 1997
Wake Forest, BA Studio Art 1991
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Factoid: Majored in Studio Art before getting into the sciences
Favorite Movie: No Country For Old Men, Whale Rider
Ancestry: Swedish.
Ability to roll tongue?: Yes.
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helena_furberg@med.unc.edu
919-966-1764
Dr. Furberg's primary research interest involves the genetics of tobacco use and nicotine dependence. She is integrating the neurobiology of addition, genetics, statistical genetics and the ethical social and legal implications (ELSI) of such research to the study of genetic contributors to nicotine dependence in a large, population-based study of Swedish twins. She is also interested in the how Swedish snus (ground, moist smokeless tobacco) impacts smoking prevalence and smoking cessation.
2006-2011 K07 National Cancer Institute Career Development Award on "Genetic Epidemiology of Nicotine Dependence" (Barnes, Anna Helena PI) PI
18023296 Sullivan PF, Kuo PH, Webb BT, Neale MC, Vittum J, Furberg H, Walsh D, Patterson DG, Riley B, Prescott CA, Kendler KS.Genomewide linkage survey of nicotine dependence phenotypes.Drug Alcohol Depend. 2007 Nov 13 (epub ahead of print). - 2007
16085503 Furberg H, Sullivan PF, Maes H, Prescott CA, Lerman C, Bulik C, Kendler KS. The types of regular cigarette smokers: a latent class analysis. Nicotine Tob Res. 2005 Jun;7(3):351-60. - 2007
Furberg H, Lichtenstein P, Pedersen NL, Bulik C, Lerman C, Sullivan PF. Snus use and other correlates of smoking cessation in the Swedish Twin Registry. Psychological Medicine, in press. - (in press)
16968353 Furberg H, Lichtenstein P, Pedersen NL, Bulik CB, Sullivan PF.Cigarettes and oral snuff use in Sweden: Prevalence and transitions. Addiction. 2006 Oct;101(10):1509-15. - 2006
16319367 Furberg H, Bulik CM, Lerman C, Lichtenstein P, Pedersen NL, Sullivan PF.Is Swedish snus associated with smoking initiation or smoking cessation?Tob Control. 2005 Dec;14(6):422-4. - 2005
16085503 Furberg H, Sullivan PF, Maes H, Prescott CA, Lerman C, Bulik C, Kendler KS.The types of regular cigarette smokers: a latent class analysis.Nicotine Tob Res. 2005 Jun;7(3):351-60. - 2005
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Molly Losh
Assistant Professor, UNC Department of Psychiatry
UC Berkeley, PhD, 2004
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Factoid: n/a
Favorite Movie: n/a
Ancestry: n/a
Ability to roll tongue?: n/a
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The overarching goal of Dr. Losh's research is to uncover gene-behavior relationships in neurogenetic disorders such as autism, to inform understanding of the basis of such disorders and lend insights into the genetic basis of language and related complex human behaviors/traits. Her research blends clinical-behavioral and genetic perspectives and methods in an attempt to disaggregate complex phenotypes in ways that might inform underlying genetic and environmental influences.
2006 - 2011 K12 RR023248 (Losh, M.; Orringer, G., PI of parent grant) UNC Multidisciplinary Clinical Research Career Development Program
2006 - 2008 Autism Speaks (Losh, M.) Characterizing the Language Endophenotype in Autism: Longitudinal, Genetic, and Neuropsychological CorrelatesThis proposal attempts to tease apart the language endophenotype in autism through examination of the early language profiles of parents of individuals with autism, and direct comparison of language and related cognitive abilities across individuals with autism and their parents.
2006 - 2008 University Research Council (Losh, M.) A Family-Genetic Study of Language in Autism
2008-2010 NIMH R03 grant to study the Fragile X premutation and potential overlap of the Broad Autism Phenotype PI
2008-2011 A 3-year NSF grant to define developmental language profiles that index genetic liability to autism among unaffected relatives. PI
No featured publications listed.
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Jim Crowley
Postdoctoal fellow
Cornell, BS, 2000
Univ. of Pennsylvania, PhD, 2005
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Factoid: I have lived in 7 different states, but always within 30 miles of a nuclear reactor.
Favorite Movie: Black Robe
Ancestry: English > Irish = French
Ability to roll tongue?: Yes
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crowley@unc.edu
Lab phone: (919) 966-9576
Cell phone: (215) 913-8776
Fax: (919) 966-3630
Tardive dyskinesia is a debilitating, unpredictable and often irreversible side effect resulting from chronic treatment with a typical antipsychotic agent. If it was possible to predict which patients were likely to develop tardive dyskinesia after typical antipsychotic use, drug treatment of schizophrenia could be made more efficacious, cost effective and safer. Dr. Crowley is using a well-validated animal model of tardive dykinesia, rodent vacuous chewing, to identify TD susceptibility genes. To achieve this, they are phenotyping 70 different inbred strains for antipsychotic-induced vacuous chewing and perfoming genome-wide association. They will test the translational importance of these findings by examining these candidate genes in TD clinical samples.
No featured grants listed.
18535926 Crowley J, Sullivan PF, McCleod HL. Untapped resources for pharmacogenomic discovery in psychiatry.Curr Opin Mol Ther. 2008 Jun;10(3):205-6. - (in press)
18286587 Crowley JJ, Keefe RS, Perkins DO, Stroup TS, Lieberman JA, Sullivan PF. The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition.Am J Med Genet B Neuropsychiatr Genet. 2008 Feb 19. - (in press)
xx Crowley JJ, Brodkin ES, Blendy JA, Berrettini WH, Lucki I. Pharmacogenomic evaluation of the antidepressant citalopram in the mouse tail suspension test. Neuropsychopharmacology. 2006 Nov;31(11):2433-42. - 2006
xx *Crowley JJ*, Lucki I. Opportunities to discover genes regulating depression and antidepressant response from rodent behavioral genetics. Current Pharmaceutical Design 2005; 11: 157-169 - 2005
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Thomas Konneker
Lab Manager
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Factoid: n/a
Favorite Movie: n/a
Ancestry: n/a
Ability to roll tongue?: n/a
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No Bio.
No featured grants listed.
No featured publications listed.
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Andrea Byrnes
Doctoral student, Biostatistics
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Factoid: n/a
Favorite Movie: n/a
Ancestry: n/a
Ability to roll tongue?: n/a
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No Bio.
No featured grants listed.
No featured publications listed.
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Cynthia Bulik, PhD
William and Jeanne Jordan Distinguished Professor of Eating Disorders
Department of Psychiatry, School of Medicine
Professor of Nutrition, School of Public Health
Director, UNC Eating Disorders Program
Univ California at Berkeley, Ph.D. Psychology (Clinical) 1988
Univ California at Berkeley, M.A. Psychology (Clinical) 1985
University of Notre Dame, B.A. Psychology, 1982
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Factoid: Ice dancing gold medalist
Favorite Movie: The Year of Living Dangerously, Top Gun
Ancestry: Czech, German, Austrian (aka European)
Ability to roll tongue?: No, sadly
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cbulik@med.unc.edu
Dr. Bulik's current research includes genetic epidemiology (family and twin studies) and molecular genetics of eating disorders and body weight regulation. She has active collaborations in Scandinavia with large population-based twin registries and birth cohorts. She is studying the impact of maternal disordered eating on fetal growth and child development in a cohort of 100,000 new births in Norway. She has ongoing collaborations in Sweden, Norway, the Netherlands, Finland, and Australia (twin studies), Latin America, Germany, and the UK (genetics and intervention), and New Zealand (intervention). In addition, she is involved with developing novel technology-assisted interventions for child overweight and adult obesity, binge-eating disorder, and eating disorders. Dr. Bulik is the Director of the first federally funded post-doctoral research training program in eating disorders.
2007-2011 National Institute of Mental Health T32MH076694
(Bulik) Postdoctoral Research Training in Eating Disorders
2007-2009 Price Foundation
(Bulik) Genetics of Anorexia Nervosa
2006-2008 National Institute of Mental Health
(Zucker) Neurodevelopmental Processes of Social Cognition in Anorexia Nervosa and Autism. Co-Investigator
2007-2012 National Institute of Mental Health R13
(Striegel-Moore) Research Teaching Day and Conference on Eating Disorders. Co-Principal Investigator
2005-2008 National Institute of Child Health and Development(Bulik) "Eating Disorders and Pregnancy Outcome in 100,000 Births" R01
2005-2010 National Institute of Child Health and Development P01 HD031921
(Harris) The National Longitudinal Study of Adolescent Health. Co-Investigator Biology Core
2005-2010 National Institute of Mental Health T32MH075854
(Popkin) UNC Interdisciplinary Obesity Training (IDOT). Co-Investigator
2005-2007 National Institute of Mental Health R21MH070781
(Bulik) "Web-Based Cognitive Therapy for Bulimia Nervosa"
2004-2008 Alexander von Humboldt-Stiftung Trans-Coop Programm
German-American Cooperation Grant
(Kordy/Bulik) Improving Care for Patients with Eating Disorders through Computer Mediated Communication
2005-2008 National Institutes of Health
(Popkin) An Interdisciplinary Strategy for Obesity/NIH Roadmap Initiative
No featured publications listed.
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Robert K. McClure
Assistant Professor, UNC Department of Psychiatry
M.D., University of Washington, 1993
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Factoid: Born and raised in the Seattle area.
Favorite Movie: Amadeus, Office Space
Ancestry: MGP emigrated from Scotland to Canada. PGP of German descent.
Ability to roll tongue?: No
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robert_mcclure@med.unc.edu
919-843-6629
My research interests are in the field of schizophrenia, neuroimaging and genetics. To successfully dissect the intricacies of underlying complex genetic diseases like schizophrenia, the integration of neuroimaging and genetics will be important. This requires understanding the principles of genetics and how to appropriately incorporate genetics into neuroimaging studies.
NARSAD Young Investigators Grant
Foundation of Hope
xx Steen RG, Mull C, McClure RK, Lieberman JL. Measurement of brain volume in first-episode schizophrenia with MRI: a systematic, critical review of cross-sectional and longitudinal studies, accepted by British Journal of Psychiatry - 2006
xx Styner M, Lieberman JA, McClure RK, Weinberger DR, Jones D, Gerig G. Morphometric analysis of lateral ventricles in normal development and schizophrenia. Proc Natl Acad Sci U S A. 2005, 102(13):4872-7 - 2005
xx McClure RK and Lieberman JA. Neurodevelopmental and neurodegenerative hypothesise of schizophrenia: a review and critique, Current Opinion in Psychiatry 2004, 16(S2):S15-S28. - 2004
xx Weinberger DR and McClure RK. (2002) Neurotoxicity, neuroplasticity, and magnetic resonance imaging, morphometry: what is happening in the schizophrenic brain? Archives of General Psychiatry 2002, 59:553-558. - 2002
xx Marenco S, Egan MF, Goldberg TE, Knable MB, McClure RK, Winterer G and Weinberger DR., Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series, Schizophrenia Research 2002, 57(2-3):221-6. - 2002
xx McClure RK and Weinberger DR. The Neurodevelopmental Hypothesis of Schizophrenia, A Review of the Evidence, Current Issues in the Psychopharmacology of Schizophrenia, Lippincott, William and Wilkins, 2001. - 2001
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Laura Marie Thornton
Data czarina
Penn State, PhD, 1992
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Factoid: Voted as the track teams most supportive parent this year - much to the dismay of my daughters.
Favorite Movie: O' Brother Where Art Thou?
Ancestry: Polish
Ability to roll tongue?: Yes
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laurathornton@comcast.net
Dr. Thornton's research interests include: eating disorders, aging, diabetes, and substance use. She is currently in charge of data coding and analysis on several projects.
No featured grants listed.
xx Pinheiro AP, Thornton LM, Plotonicov KH, Tozzi T, Klump KL, Berrettini WH, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel P, LaVia M, Mitchell J, Rotondo A, Strober M, Treasure J, Woodside DB, Von Holle A, Hamer R, Kaye WK, Bulik CM (2007). Patterns of menstrual disturbance in eating disorders. International Journal of Eating Disorders, 40, 424-434. - 2007
xx Thornton LM, Hahn, ME, Schanz N. (2005). Genetic and developmental influences on infant mouse ultrasonic calling. III. Patterns of inheritance in the calls of mice 3-9 days of age. Behavior Genetics, 35, 73-83. - 2005
xx Reba L, Thornton L, Tozzi F, Klump KL, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, Keel P, LaVia M, Mitchell J, Strober M, Woodside DB, Rotondo A, Berrettini WH, Kaye WH, Bulik CM. Relationships between features associated with vomiting in purging-type eating disorders. (2005). International Journal of Eating Disorders, 38, 287-294. - 2005
xx Ross DE, Kirkpatrick B, Karkowski LM, Straub RE, MacLean CJ, O'Neill FA, Compton AD, Murphy B, Walsh D, Kendler KS. (2000). Sibling correlation of the deficit syndrome in the Irish Study of High-Density Schizophrenia Families. American Journal of Psychiatry, 157, 071-1076. - 2000
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Tammy Root
Postdoctoral fellow
Ph.D. (2007); The Pennsylvania State University; Human Development and Family Studies
M.A.S. (2006); The Pennsylvania State University; Statistics
M.A. (2002); California State University, Fullerton; Psychology
B.A. (1999); Chapman University; Psychology
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Factoid: My dog Frenchie (see favorite movie below!) has been with me through all my degrees -- BA, MA, MAS, and PhD. Thus, she has moved from CA to PA to NC.
Favorite Movie: Grease (not intellectually stimulating by any means, but fun and timeless!)
Ancestry: English and Dutch
Ability to roll tongue?: Yep
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tammy_root@med.unc.edu
Ph: 919-843-8721
Fax: 919-966-5628
Tammy L. Root, Ph.D., is a Postdoctoral Fellow in Eating Disorders in the School of Medicine in the Department of Psychiatry at the University of North Carolina at Chapel Hill. Dr. Root received her Ph.D. from the Department of Human Development and Family Studies at The Pennsylvania State University. Dr. Root has two general research interests: (1) eating disorders and (2) developmental research methodology. She is primarily interested in examining the relation between eating disorders and substance use from both a phenotypic and genetic perspective. Her goal is to elucidate the current knowledge on this comorbidity in hopes of better informing prevention and treatment efforts, while simultaneously applying the most current and innovative methodology for best answering the research questions.
Dr. Root is also interested in the methodological advancement of discrete latent variable modeling, particularly latent class analysis. In 2006 Dr. Root received a Predoctoral Fellowship from the National Institute on Drug Abuse. Her dissertation research, motivated by the small sample sizes typically found in eating disorder research, focused on expanding the latent class model to include informative prior distributions. Doing so improves parameter estimation as well as issues related to empirical identification, particularly when sample sizes are small in relation to the complexity of the model being tested.
2005 Title:Small Sample Methodology for Drug Use Research
Grant:NIH/NIDA 1 F31 DA020307-01
Period:9/1/05-5/1/08 (completed 9/4/07)
Amount:$104,157 total award
PI
No featured publications listed.
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Rebecca Knickmeyer
Assistant Professor
BA Goucher College 2000
PhD University of Cambridge 2005
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Factoid: Represented England in 3 Latin Formation World Championships (despite being an American citizen)
Favorite Movie: Groundhog Day, Rear Window
Ancestry: German with Danish, English, Luxemburgish, and French.
Ability to roll tongue?: No (sigh)
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rebecca_knickmeyer@med.unc.edu
919-966-2216
Dr. Knickmeyer's primary research interest is in the biological mechanisms contributing to sexual differentiation of the human brain and to sex differences in the prevalence and expression of psychiatric disorders. She is currently investigating whether individual variation in genes involved in gonadal steroid signaling predicts individual variation in early brain development as assessed via high resolution MRI.
National Alliance for Autism Research Biomedical Grant (now Autism Speaks)
Foundation of Hope
xx Knickmeyer, R.C., & Baron-Cohen, S. (2006). Fetal testosterone and sex differences in typical social development and in autism. Journal of Child Neurology. 21:825-845. - 2006
xx Knickmeyer, R., Taylor, K., Raggatt, P., Hackett, G., & Baron-Cohen, S. (2006) Fetal testosterone and empathy. Hormones and Behavior. 49 (3):282-292. - 2006
xx Knickmeyer, R.C., Baron-Cohen, S., Fane, B.A., Wheelwright, S., Mathews, G., Conway, G.S. Brook, C.D.G., & Hines, M. (2006). Androgens and autistic traits: A study of individuals with Congenital Adrenal Hyperplasia . Hormones and Behavior. 50(1):148-153. - 2006
xx Knickmeyer, R.C., Vetsa, Y.S.K., Moore, B., Gerig, G., & Gilmore, J. (2006) A proxy measure of prenatal testosterone exposure is related to gray matter volume in human neonates. Abstract book, 23rd International Neurotoxicology Conference (Neurotoxicity in Development and Aging), Little Rock, Arkansas. - 2006
xx Baron-Cohen, S., Knickmeyer, R.C., & Belmonte, M. (2005) Sex differences in the brain: Implications for explaining autism. Science. 310(5749): 819-823. - 2005
xx Knickmeyer, R.C., Wheelwright, S., Taylor, K., Raggatt, P., Hackett, G., & Baron-Cohen, S. (2005) Gender-typed play and amniotic testosterone. Developmental Psychology 41(3):517-528. - 2005
xx Knickmeyer, R.C., Baron-Cohen, S., Raggatt, P., & Taylor, K. (2005) Foetal testosterone, social relationships and restricted interests in children. Journal of Child Psychology and Psychiatry and Allied Disciplines. 46(2):198-210. - 2005
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Lauren Reba-Harrelson
Doctorol student, Clinical Psychology
Brown University, A.B., 2000
University of North Carolina at Chapel Hill, M.A., 2006
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Factoid: I have a 170 lb blue great dane named Victor.
Favorite Movie: The Apartment, A Nightmare before Christmas
Ancestry: 1/2 Swedish & 1/2 Serbo-Croatian
Ability to roll tongue?: Yes
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lreba@med.unc.edu
Lauren's interests lie in the psychopathology, treatment, stigmatization, and genetics of eating disorders; ideally, progress in the area of genetics will ultimately have a significant impact on the three former areas. The topic of her dissertation focuses on feeding practices of mothers with eating disorders and eating & psychological symptoms in their offspring in the prospective Norwegian Mother and Child Cohort study.
Ruth L. Kirschstein National Research Service Award (F31)
xx Reba-Harrelson, L., Von Holle, A., Thornton, L., Tozzi, F., Klump, K., Brandt, H., Crawford, S., Crow, S., Fichter, M.F. , Halmi, K., Johnson, C., Kaplan, A., Keel, P., LaVia, M. , Mitchell, J., Strober, M., Woodside, B.D., Rotondo, A., Berrettini, W.H., Kaye, W., Bulik, C.M. (in press). Features associated with diet pill use in individuals with eating disorders, Eating Behaviors. - 2007
xx Reba, L., Thornton, L., Tozzi, F., Klump, K., Brandt, H., Crawford, S., Crow, S., Fichter, M.F., Halmi, K., Johnson, C., Kaplan, A., Keel, P., LaVia, M. , Mitchell, J., Strober, M., Woodside, B.D., Rotondo, A., Berrettini, W.H., Kaye, W., Bulik, C.M. (2005). Features associated with vomiting in purging-type eating disorders. International Journal of Eating Disorders, 38(4):287-94. - 2005
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